Journal of Experimental Stroke & Transitional Medicine
Background and Purpose: The lack of reliable rodent model for repeated ischemia-reperfusion (I-R) hampers experimental research on stroke. Therefore, the objective of the present study was to develop a mouse model for repeated I-R cycles in a single animal on different Continue Reading
A stroke may occur to anyone without warning. The main cause is stopping the blood flow to the brain. The result is that the brain cells are left without oxygen, and damaged parts of the brain cannot perform their functions. Continue Reading
Every year, almost a million people in the USA, 75% of whom are aged over 65, will suffer from a stroke, losing brain function due to a blockage in its blood supply. It has been estimated that around 15 million Continue Reading
Discussion In the present study G-2MePE treatment, by a single dose SC administration significantly reduced the extent of brain damage after HI injury. Attenuation of brain damage, neuronal loss and apoptosis were associated with reduced microglial reaction, TNF-α expression and Continue Reading
Discussion In this study, we show that the expression of CCRL2, a chemokine receptor, is up-regulated in mouse brain slices under ischemic conditions. The deletion of CCRL2 not only reduced the ischemia-induced cell death in brain slices but attenuated tMCAO-induced Continue Reading
Abstract Impairments caused by stroke remain the main cause for adult disability. Despite a vigorous research effort, only 1 thrombolytic treatment has been approved in acute stroke (<3h). The limitations of preclinical studies and how these can be overcome Continue Reading
Abstract Although acute ischemic stroke has high mortality and morbidity rate but yet still has very limited treatment. In this study we have tested the concept of neuron protection by acute bioenergetic intervention or by pharmacological preconditioning with natural antioxidants. Continue Reading
Abstract Background and Purpose: Hypoxic-ischemic brain injury, due to reduced supply of oxygen to brain, is a major cause of death and disability. There is no exclusive treatment available so far. Glycine-2-Methylproline-Glutamate (G-2MePE, NNZ 2566), an analogue of Glycine-Proline-Glutamate reduces Continue Reading
Abstract We examined the role of CCRL2 in ischemic brain injury using both in vitro and in vivo mouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein levels in cultured brain slices under ischemic Continue Reading
Abstract Objectives: Transient postoperative hyperperfusion may be the cause of the temporary neurologic deterioration (TND) frequently observed following superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery. The purpose of this study is to investigate the possible factors influencing postoperative temporary Continue Reading